THROMBOSIS OF THE BRAIN SINUSES DEVELOPED DUE TO CIRCULATION OF ADAMTS13-PROTEASE INHIBITOR DURING POSTPARTUM PERIOD (CLINICAL CASE)

ADAMTS13-protease defects have been reported to be the cause of cerebral stroke and myocardial infarction. A clinical case is discussed: the patient had a history of three stillbirths (at 28, 24 and 32 weeks of pregnancy). After the third stillbirth, on the 5th day of hospitalization developed thrombosis of the cerebral sinuses. 6 years after the thrombosis episode, the patient planed a pregnancy. As a result of the studies, increased ADAMTS13-protease inhibitor was revealed. Pregnancy occurred in 6 months. During the pregnancy patient took the anticoagulant and aspirin therapy under monitoring of the haemostasis system. At the 39 weeks planned caesarean section was born a healthy female new-born with a weight of 2100 gr, length of 49 cm. Anticoagulant therapy was continued during postpartum period. There was no recurrence of thrombotic complications.