The incorporation of MALDI mass spectrometry imaging in studies to identify markers of toxicity following in utero opioid exposures in mouse fetuses
The observed differential glycerophospholipid distributions in relation to treatment and NTD development in mouse fetuses provide potential targets for further investigation of molecular mechanisms of opioid-related developmental effects. Overall, these findings support the feasibility of incorporating MALDI MSI to assess non-standard endpoints of opioid exposure during gestation.
Authors
- E. Ellen Jones (ORCID: https://orcid.org/0000-0002-2325-7904)
- Pravin R. Kaldhone
- Sumit Sarkar (ORCID: https://orcid.org/0000-0001-6255-8809)
- Joseph P. Hanig
- Kelly J. Davis (ORCID: https://orcid.org/0000-0002-3597-8338)
- Grace S. Lee (ORCID: https://orcid.org/0000-0001-7648-4150)
- Amy L. Inselman (ORCID: https://orcid.org/0000-0002-3335-7482)
- Pritpal Malhi (ORCID: https://orcid.org/0000-0002-2924-0054)
- Dustyn A. Barnette (ORCID: https://orcid.org/0000-0001-5048-2982)
- Richard D. Beger (ORCID: https://orcid.org/0000-0003-4380-2356)
- J. Edward Fisher
Institutions
- National Center for Toxicological Research (US)
- Center for Drug Evaluation and Research (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3389/ftox.2024.1452974
- Citations
- 1
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.24