Evaluation of Antihypertensive Activity of Methanolic Leaf Extract of Adina cordifoliausing a Fructose-Induced Hypertensive Rat Model

A common cardiovascular condition, hypertension remains a major global public health concern. Using an in-vivo method, this study sought to assess the methanolic extract made from Adina cordifolia leaves' possible anti-hypertensive properties. Male Wistar rats were split up into groups and given varied amounts of the methanolic extract. The non-invasive tail-cuff method was used to test blood pressure at regular intervals after extract administration. Biochemical measures such as lipid profiles and kidney function tests were also evaluated to determine the extract's safety and effectiveness. Rats given the extract showed a dose-dependent drop in blood pressure, with the systolic and diastolic blood pressures much lower than those of the control group. Additionally, the extract showed no discernible negative effects on renal function or lipid profile, suggesting it may be safe for therapeutic use. These results imply that Adina cordifolia Linn's methanolic extract has encouraging anti-hypertensive qualities, indicating the need for additional research into its potential as a treatment for hypertension.