One-Pot Synthesis of Hydroxylated Alkaloids from Sugars via a Pictet–Spengler-Type Reaction
An efficient and convenient strategy has been successfully developed for the preparation of novel hydroxylated alkaloid derivatives (also called fused multicyclic iminosugars) from <i>p</i>-toluenesulfonylated sugars through a Pictet-Spengler-type mechanism. This method is highly stereoselective, does not require metal catalysts, and capable of conducting gram level reactions (with a 53% yield). Some of such iminosugars had an intermediate antiproliferative effect on HCT116 tumor cells.
Authors
- Chen Hua (ORCID: https://orcid.org/0000-0002-3066-7434)
- Jilai Wu (ORCID: https://orcid.org/0000-0002-8236-0709)
- Likai Zhou
- Feng Liu (ORCID: https://orcid.org/0009-0005-1040-2999)
- Song Xie
- Na Ma
- Weilin Yang
- Lili Wang
Institutions
- Hebei University (CN)
- Xingtai University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2024-12-03
- DOI
- https://doi.org/10.3390/molecules29235709
- Citations
- 2
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province
- Hebei University