Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
The activation of ASIC1A prevents NSC differentiation into oligodendrocytes via the transcellular NSC-to-NSC delivery of PGE2, resulting in the failure of myelin sheath regeneration and axonal remyelination following SCI. The inhibition of ASIC1A presents a promising therapeutic strategy for the treatment of SCI.
Authors
- Yixiang Dong
- Zuomeng Wu
- Tianyu Han (ORCID: https://orcid.org/0000-0002-1471-611X)
- Yunlei Liu
- Ying Wang (ORCID: https://orcid.org/0000-0002-5554-6292)
- Huang Fang (ORCID: https://orcid.org/0000-0002-6204-6552)
- Peiwen Song (ORCID: https://orcid.org/0000-0001-7423-3729)
- Cailiang Shen (ORCID: https://orcid.org/0009-0009-8049-4576)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s11658-024-00672-9
- Citations
- 10
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Anhui Provincial Key Research and Development Plan