Responses to the activation of different intranasal trigeminal receptors: Evidence from behavioral, peripheral and central levels

Activation of different intranasal trigeminal receptors yields varied responses. Notably, stimuli involving TRPV1 activation, linked to irritation or pain, elicited stronger behavioral and neural activity compared to stimuli involving other receptors, even when controlling for rated stimulus intensity. This emphasizes TRPV1's significance in survival adaptation. Future studies should test different sets of stimulants to verify the robustness of these findings.