Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial Cells
GERD causes dysregulation of cellular proteostasis, accumulation of isoLG protein adducts, misfolded, and aggregated proteins that promote ferroptotic cell death. Taken together, this study suggests that GERD has similarities to other known pathologic conditions that are characterized by protein misfolding and aggregation.
Authors
- Wael El‐Rifai (ORCID: https://orcid.org/0000-0003-2101-6098)
- Kodisundaram Paulrasu (ORCID: https://orcid.org/0000-0001-6771-0961)
- Alexander Zaika (ORCID: https://orcid.org/0000-0001-6760-2020)
- Karoline J. Briegel (ORCID: https://orcid.org/0000-0003-2661-509X)
- Jianwen Que (ORCID: https://orcid.org/0000-0002-6540-6701)
- Mónica García-Buitrago (ORCID: https://orcid.org/0000-0003-1146-4284)
- Olivier G. Boutaud (ORCID: https://orcid.org/0000-0002-8910-0598)
- Ravindran Caspa Gokulan (ORCID: https://orcid.org/0000-0001-7077-8297)
- Sergey Dikalov (ORCID: https://orcid.org/0000-0003-2976-6184)
- Timothy C. Wang
- Zhibin Chen (ORCID: https://orcid.org/0000-0002-2865-8416)
Institutions
- University of Miami (US)
- Vanderbilt University (US)
- Columbia University Irving Medical Center (US)
- University of Miami Hospital (US)
- Clinical Pharmacology of Miami (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101434
- Citations
- 2
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- U.S. Department of Veterans Affairs
- University of Miami
- Sylvester Comprehensive Cancer Center, University of Miami Health Systems
- National Institutes of Health
- National Cancer Institute