CRISPR/Cas9-induced double-strand breaks in the huntingtin locus lead to CAG repeat contraction through DNA end resection and homology-mediated repair
Our study provides new insights into the complex mechanisms of CRISPR/Cas9-induced shortening of CAG repeats in human cells.
Authors
- Paweł Śledziński (ORCID: https://orcid.org/0000-0002-4671-5189)
- Marta Olejniczak (ORCID: https://orcid.org/0000-0001-8471-6302)
- Mateusz Nowaczyk
- Marianna Iga Smielowska
Institutions
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (PL)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12915-024-02079-6
- Citations
- 4
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- European Regional Development Fund