Cerebrospinal Fluid Biomarkers of Central Nervous System Inflammation Predict Cortical Decline in Bipolar Disorder and Ventricular Enlargement in Healthy Controls
These findings suggest that CSF IL-8 may contribute to cortical decline in bipolar disorder. The lack of association between serum biomarkers and brain changes highlights the specificity of CNS inflammation in these processes. Additionally, the observed link between CSF YKL-40 and ventricular enlargement in healthy controls may indicate a role of CNS inflammation processes in normal brain aging.
Authors
- Anna Luisa Klahn (ORCID: https://orcid.org/0000-0002-9189-6687)
- Tor Johansson
- Mikael Landén (ORCID: https://orcid.org/0000-0002-4496-6451)
- Christoph Abé (ORCID: https://orcid.org/0000-0002-1680-8480)
- Carl M. Sellgren (ORCID: https://orcid.org/0000-0001-9103-2785)
- Andreas Göteson (ORCID: https://orcid.org/0000-0001-6118-6054)
Institutions
- Karolinska Institutet (SE)
- Stockholm Health Care Services (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Neuropsychobiology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1159/000542888
- Citations
- 3
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.16