High glucose induces podocyte ferroptosis through BAP1/SLC7A11 pathway
HG inhibits cystine uptake in podocytes by promoting the expression of BAP1 and inhibiting H2Aub deubiquitination on SLC7A11, leading to lipid peroxide accumulation and ferroptosis in podocytes.
Authors
- Jianguang Gong (ORCID: https://orcid.org/0000-0001-8690-9669)
- Juan Jin (ORCID: https://orcid.org/0000-0003-2725-8098)
- Zheng Danna
- Wenbo Sun (ORCID: https://orcid.org/0000-0002-5301-4938)
- Qiang He
- Peiyao Ren (ORCID: https://orcid.org/0000-0001-8247-6544)
- Man Xueli
Institutions
- Zhejiang Chinese Medical University (CN)
- Chinese University of Hong Kong (HK)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40590
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- National Natural Science Foundation of China
- State Administration of Traditional Chinese Medicine of the People's Republic of China
- Natural Science Foundation of Zhejiang Province