Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Pdpn<sup>+</sup> macrophages exhibit significant vascular protective effects by alleviating insulin resistance and modulating adipokine/cytokine expression in PVAT adipocytes. This macrophage subtype may therefore play pivotal roles in mitigating vascular complications in T2DM. Our findings also underscore the critical role of immune-metabolic cross-talk in maintaining tissue homeostasis.
Authors
- Qunye Zhang
- Junfei Gu (ORCID: https://orcid.org/0000-0003-0002-0725)
- Panpan Xie (ORCID: https://orcid.org/0009-0003-3020-9083)
- Xuefang Yan
- Shucui Zhang (ORCID: https://orcid.org/0000-0002-7164-5784)
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-6146-9780)
- Xiaowei Wang (ORCID: https://orcid.org/0000-0002-4035-161X)
- Zhe Wang (ORCID: https://orcid.org/0000-0002-4950-9954)
- Jiajia Jin
- Haiyan Lin (ORCID: https://orcid.org/0000-0002-5771-3947)
- Xinjie Zhang (ORCID: https://orcid.org/0009-0006-0476-1933)
- Yingjie Wu (ORCID: https://orcid.org/0000-0001-8326-4973)
- Zhenyu Tian (ORCID: https://orcid.org/0000-0003-0385-1460)
- Dong Guo
- Tongxue Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Provincial Hospital (CN)
- Ministry of Education (TH)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
- University College London (GB)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s11658-024-00668-5
- Citations
- 6
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China