Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases
DNA methylation analyses provide a robust method for distinguishing PM from healthy pleural tissues, and specific methylation patterns exist within PM subtypes. These methylation differences underscore their importance in understanding disease progression and may serve as viable biomarkers or therapeutic targets. Moreover, differential methylation patterns between PM and other lung cancers highlights its diagnostic potential. These findings necessitate further translational studies to explore their clinical applications.
Authors
- Guy Van Camp (ORCID: https://orcid.org/0000-0001-5105-9000)
- Jo Raskin (ORCID: https://orcid.org/0000-0001-8029-4093)
- Dieter Peeters (ORCID: https://orcid.org/0000-0002-6943-2675)
- Jeroen Hendriks (ORCID: https://orcid.org/0000-0003-4326-9256)
- Ken Op de Beeck (ORCID: https://orcid.org/0000-0001-5527-6838)
- Janah Vandenhoeck (ORCID: https://orcid.org/0000-0003-2358-8671)
- Paul Van Schil (ORCID: https://orcid.org/0000-0002-1962-8821)
- Joe Ibrahim (ORCID: https://orcid.org/0000-0001-9728-5273)
- Jan P. van Meerbeeck (ORCID: https://orcid.org/0000-0001-7872-8622)
- Nele De Meulenaere (ORCID: https://orcid.org/0000-0003-3390-5220)
Institutions
- University of Antwerp (BE)
- Antwerp University Hospital (BE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s13148-024-01790-z
- Citations
- 4
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Stichting Tegen Kanker
- Universiteit Antwerpen