Synthesis of tetrasubstituted furans through a Cu/base-mediated cascade reaction from terminal alkynes and 1,2-diketones
The expeditious construction of tetrasubstituted furans <i>via</i> Cu/base-promoted cascade reactions of terminal alkynes with 1,2-diketones is described. This reaction proceeds smoothly, involving the formation of multiple chemical bonds tolerating a wide range of functional groups. The mechanism underlying these transformations has been thoroughly investigated, suggesting that 1,3-diyne serves as a key intermediate generated <i>in situ</i> through oxidative coupling facilitated by the Cu catalyst.
Authors
- Yujun Liu (ORCID: https://orcid.org/0000-0002-4609-3666)
- Xian Liang (ORCID: https://orcid.org/0000-0002-8420-8137)
- Liangliang Yao
- Shuwen Xu (ORCID: https://orcid.org/0000-0002-3557-5897)
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Yating Wang (ORCID: https://orcid.org/0000-0002-8470-0148)
- Jian Fan (ORCID: https://orcid.org/0009-0001-2865-8360)
- Bangben Yao (ORCID: https://orcid.org/0000-0002-5899-2976)
Institutions
- Anhui Jianzhu University (CN)
- University of Science and Technology of China (CN)
- Hefei Institutes of Physical Science (CN)
- Anhui Academy of Agricultural Sciences (CN)
- Ningbo Product Quality Supervision and Inspection Institute (CN)
- Chuzhou University (CN)
- Anhui Academy of Medical Sciences (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1039/d4ob01785d
- Citations
- 1
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.25