Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model
EA commonly protects dopaminergic neuronsby reducing neuroinflammation, oxidative stress, and apoptosis. New findings reveal that EA alleviates motor symptoms in a parkinsonian rat model without restoring striatal dopamine levels. EA effectively suppresses excessiveglutamate transmission and high-beta synchronization, contributing to motorsymptom relief. Activation of corticostriatalglutamatergic projections may hinder the efficacy of EA.
Authors
- Min Sun (ORCID: https://orcid.org/0000-0002-8528-0050)
- Peirong Liang
- Xinyu Fan (ORCID: https://orcid.org/0000-0001-6637-5444)
- Zirui Wang (ORCID: https://orcid.org/0000-0003-0626-742X)
- Ke Wang (ORCID: https://orcid.org/0000-0002-2474-8019)
- Jun Jia (ORCID: https://orcid.org/0000-0002-3801-9562)
- Xinxin Jiang (ORCID: https://orcid.org/0000-0002-6402-578X)
- Wei Jing (ORCID: https://orcid.org/0000-0002-8794-7832)
- Xiaomin Wang (ORCID: https://orcid.org/0000-0001-8601-3053)
- Jihan Wang (ORCID: https://orcid.org/0000-0003-1143-363X)
- Yitong Yan
- Yanhua Wang
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/ctm2.70117
- Citations
- 8
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.73
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality