Seamless trials in oncology: A cross-sectional analysis of characteristics and reporting
Our study provides cross-sectional data on seamless early-phase oncology trials registered on ClinicalTrials.gov. We highlight the challenges of the evolving clinical trial design landscape and the problem of missing results in the seamless design context, which raises serious ethical concerns. Efforts should be made to adapt the functionality of the ClinicalTrials.gov database to emerging clinical trial models.
Authors
- Katarzyna Klaś (ORCID: https://orcid.org/0000-0001-8230-5577)
- Alicja Włodarczyk
- Marcin Waligóra (ORCID: https://orcid.org/0000-0002-1553-1416)
- Paola Buedo (ORCID: https://orcid.org/0000-0002-1913-5728)
- Maciej Polak (ORCID: https://orcid.org/0000-0003-1290-8692)
- Karolina Strzebońska (ORCID: https://orcid.org/0000-0003-2652-2635)
- Samuel Gordon (ORCID: https://orcid.org/0009-0000-8224-5447)
- Paulina Kaszuba
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1371/journal.pone.0312797
- Primary Topic
- Ethics in Clinical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00