Inhibitory effect of Zhujing Pill on myopia progression: Mechanistic insights based on metabonomics and network pharmacology
This investigation provides the first evidence of ZJP's multifaceted effectiveness in managing myopia, highlighting its impact on multiple components, targets, and pathways, including the novel involvement of LPCAT1 and CHRNA7 in myopia pathogenesis.
Authors
- Xin Zhou (ORCID: https://orcid.org/0000-0002-4317-7354)
- Jiawen Li (ORCID: https://orcid.org/0009-0003-4285-6958)
- Yongle Du (ORCID: https://orcid.org/0000-0002-5727-3355)
- Yufeng Han (ORCID: https://orcid.org/0000-0002-9217-0941)
- Ruyue Geng
- Dadong Guo (ORCID: https://orcid.org/0000-0002-1712-0055)
- Ruixue Zhang (ORCID: https://orcid.org/0000-0002-1002-0713)
- Haoyu Chen (ORCID: https://orcid.org/0000-0001-7618-9733)
- Hongsheng Bi (ORCID: https://orcid.org/0000-0002-6965-9626)
- Linqi Yang (ORCID: https://orcid.org/0000-0002-0704-831X)
- Miaomiao Pang
- Jinpeng Liu (ORCID: https://orcid.org/0009-0008-4305-8305)
- Yanan Zhang (ORCID: https://orcid.org/0009-0007-7580-2293)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong Shierming Eye Hospital (CN)
- Shandong Eye Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1371/journal.pone.0312379
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China