A corollary discharge circuit in human speech
When we vocalize, our brain distinguishes self-generated sounds from external ones. A corollary discharge signal supports this function in animals; however, in humans, its exact origin and temporal dynamics remain unknown. We report electrocorticographic recordings in neurosurgical patients and a connectivity analysis framework based on Granger causality that reveals major neural communications. We find a reproducible source for corollary discharge across multiple speech production paradigms localized to the ventral speech motor cortex before speech articulation. The uncovered discharge predicts the degree of auditory cortex suppression during speech, its well-documented consequence. These results reveal the human corollary discharge source and timing with far-reaching implication for speech motor-control as well as auditory hallucinations in human psychosis.
Authors
- Patricia Dugan (ORCID: https://orcid.org/0000-0001-6199-1870)
- Orrin Devinsky (ORCID: https://orcid.org/0000-0003-0044-4632)
- Amirhossein Khalilian-Gourtani (ORCID: https://orcid.org/0000-0003-1376-9583)
- Leyao Yu (ORCID: https://orcid.org/0009-0003-8998-1545)
- Ran Wang (ORCID: https://orcid.org/0000-0002-4204-4576)
- Werner Doyle (ORCID: https://orcid.org/0000-0001-7138-9701)
- Xupeng Chen (ORCID: https://orcid.org/0009-0003-3519-1863)
- Adeen Flinker (ORCID: https://orcid.org/0000-0003-1247-1283)
- Yao Wang (ORCID: https://orcid.org/0009-0001-4577-7708)
- D. B. Friedman (ORCID: https://orcid.org/0009-0002-5197-4983)
Institutions
- Neurology, Inc (US)
- New York University (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1073/pnas.2404121121
- Citations
- 15
- Primary Topic
- Neuroscience and Music Perception
- Type
- article
- Field-Weighted Citation Impact
- 5.14
Funders
- National Science Foundation
- National Institute of Neurological Disorders and Stroke