Serum Proteins Predict Treatment-Related Cardiomyopathy Among Survivors of Childhood Cancer
A risk model was developed on the basis of the differential expression of serum proteins in subclinical cardiomyopathy, which accurately discriminated the risk for severe cardiomyopathy in an independent, matched sample. Further assessment of these proteins as biomarkers of cardiomyopathy risk should be conducted in external larger cohorts and through prospective studies.
Authors
- Qian Li (ORCID: https://orcid.org/0000-0001-9874-3555)
- Junmin Peng (ORCID: https://orcid.org/0000-0003-0472-7648)
- Anthony A. High (ORCID: https://orcid.org/0000-0003-2323-5649)
- Yutaka Yasui (ORCID: https://orcid.org/0000-0002-7717-8638)
- Daniel A. Mulrooney (ORCID: https://orcid.org/0000-0003-2351-9115)
- John L. Jefferies (ORCID: https://orcid.org/0000-0002-4046-2352)
- Yadav Sapkota (ORCID: https://orcid.org/0000-0001-5943-9454)
- Kirsten K. Ness (ORCID: https://orcid.org/0000-0002-2084-1507)
- Kendrick Li
- Haiyan Tan (ORCID: https://orcid.org/0000-0001-6687-2563)
- Smita Bhatia (ORCID: https://orcid.org/0000-0002-7755-5683)
- Him K. Shrestha (ORCID: https://orcid.org/0000-0001-9686-357X)
- Suresh Poudel (ORCID: https://orcid.org/0000-0003-2333-3556)
- Suiping Zhou (ORCID: https://orcid.org/0000-0003-0914-066X)
- Leslie L. Robison (ORCID: https://orcid.org/0000-0001-7460-8578)
- Matthew J. Ehrhardt (ORCID: https://orcid.org/0000-0003-2781-9983)
- Gregory T. Armstrong (ORCID: https://orcid.org/0000-0001-8722-4207)
- Stephanie B. Dixon (ORCID: https://orcid.org/0000-0003-3901-3274)
- Bonnie Ky (ORCID: https://orcid.org/0000-0002-6628-9981)
- Cindy Im (ORCID: https://orcid.org/0000-0003-0931-9432)
- Melissa M. Hudson (ORCID: https://orcid.org/0000-0001-6984-2407)
- Paul W. Burridge (ORCID: https://orcid.org/0000-0001-9616-0006)
- Yue Pan
Institutions
- Northwestern University (US)
- University of Minnesota (US)
- St. Jude Children's Research Hospital (US)
- University of Tennessee Health Science Center (US)
- University of Alabama at Birmingham (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- JACC CardioOncology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1016/j.jaccao.2024.10.004
- Citations
- 6
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.41
Funders
- National Cancer Institute