TNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury
Prompt systemic administration of TNF-α inhibitor prevents LSC deficiency and facilitates corneal reepithelialization after alkali burn. TNF-α suppression may benefit the outcomes of other ocular injuries that cause LSC deficiency.
Authors
- Eleftherios I. Paschalis (ORCID: https://orcid.org/0000-0002-4544-4452)
- Fengyang Lei (ORCID: https://orcid.org/0000-0002-9169-8314)
- Reza Dana (ORCID: https://orcid.org/0000-0002-5732-5100)
- James Chodosh (ORCID: https://orcid.org/0000-0002-7463-1599)
- Mirja Mittermaier (ORCID: https://orcid.org/0000-0003-0678-6676)
- Claes H. Dohlman (ORCID: https://orcid.org/0000-0002-6120-8177)
- Chengxin Zhou (ORCID: https://orcid.org/0000-0003-3215-068X)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- University of New Mexico (US)
- Smith-Kettlewell Eye Research Institute (US)
Publication Details
- Journal
- Cornea
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1097/ico.0000000000003738
- Citations
- 4
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- Massachusetts Eye and Ear
- National Institute of General Medical Sciences
- National Institute of Environmental Health Sciences