Oxyresveratrol and/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-γ/Nrf-2/HO-1, NF-κB/TNF-α/Keap-1, and Bcl-2/Caspase-3/ATG-5 signaling pathways in rats
The current study's findings suggest that ORES and/or DAPA pretreatment could be a viable therapeutic approach to ameliorate DOX-induced nephrotoxicity.
Authors
- Waleed S M El-Sawy
- Ali H. El‐Bahrawy
- Ramadan A.M. Hemeida (ORCID: https://orcid.org/0009-0000-1870-9585)
- Basim Anwar Shehata Messiha (ORCID: https://orcid.org/0000-0002-5476-1409)
- Marwa M. Khalaf
Institutions
- Beni-Suef University (EG)
- Al-Azhar University (EG)
- Deraya University
- Assiut University (EG)
Publication Details
- Journal
- Naunyn-Schmiedeberg s Archives of Pharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1007/s00210-024-03608-4
- Citations
- 7
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Beni-Suef University