Human liver stem cells and derived extracellular vesicles protect from sepsis-induced acute lung injury and restore bone marrow myelopoiesis in a murine model of sepsis
Treatment with HLSCs or HLSC-derived EVs was effective in improving acute lung injury, dysmyelopoiesis and ultimately survival in this experimental murine model of lethal sepsis.
Authors
- Luisa Delsedime (ORCID: https://orcid.org/0000-0002-3564-598X)
- Lorenzo Del Sorbo (ORCID: https://orcid.org/0000-0003-3294-9838)
- Andrea Costamagna (ORCID: https://orcid.org/0000-0003-1259-7476)
- Vito Fanelli (ORCID: https://orcid.org/0000-0002-1647-2411)
- Giovanni Camussi (ORCID: https://orcid.org/0000-0003-2795-232X)
- Víctor Navarro-Tableros (ORCID: https://orcid.org/0000-0001-7629-1199)
- Sara Lamorte (ORCID: https://orcid.org/0000-0003-4579-2948)
- Chiara Pasquino
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Turin (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s40635-024-00701-z
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Università degli Studi di Torino
- Regione Piemonte