Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration
APL from P-PRP decreased ROS levels in an IVDD in vitro model, mediated autophagy in dysfunctional mitochondria, and alleviated inflammation via the SIRT1-PINK1/Parkin pathway.
Authors
- Guang Yang (ORCID: https://orcid.org/0000-0002-5272-9384)
- Jie Bai (ORCID: https://orcid.org/0000-0002-0127-4623)
- Zhili Ding (ORCID: https://orcid.org/0000-0002-7161-5649)
- Wei Du (ORCID: https://orcid.org/0000-0001-8705-1983)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-9126-4922)
- Yu Ding (ORCID: https://orcid.org/0000-0003-1783-5461)
- Jiaheng Han
- Jie Huang (ORCID: https://orcid.org/0000-0003-3778-3902)
Institutions
- Anhui Medical University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1016/j.intimp.2024.113700
- Citations
- 5
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China