Evolution of Rapid Clonal Dynamics and Non–Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer
These findings suggest rational strategies for combining sequential chemotherapy and BRAF-/EGFR-directed therapy in BRAF-V600E-mutant colon cancer to prevent resistance and improve outcome. The data demonstrate rapid clonal dynamics in response to effective therapies in BRAF-V600E-mutant colon cancer that can be monitored by serial cfDNA analysis. Moreover, in mismatch repair-proficient BRAF-V600E-mutant colon cancers, combined EGFR and BRAF/MEK therapy is not cross-resistant with standard chemotherapy, suggesting new rational combination treatment strategies.
Authors
- Gregory Riedlinger (ORCID: https://orcid.org/0000-0001-5690-7777)
- Howard S. Höchster (ORCID: https://orcid.org/0000-0002-9893-1529)
- Hossein Khiabanian (ORCID: https://orcid.org/0000-0003-1446-4394)
- Atul Kulkarni (ORCID: https://orcid.org/0000-0003-1696-4982)
- Kevin Tong (ORCID: https://orcid.org/0009-0002-6371-4644)
- Om A. Kothari (ORCID: https://orcid.org/0000-0002-0694-3646)
- Michael P. Verzi (ORCID: https://orcid.org/0000-0003-4082-4330)
- Vasudeva Ginjala (ORCID: https://orcid.org/0000-0002-1978-455X)
- Roman Groisberg (ORCID: https://orcid.org/0000-0001-8970-7675)
- Jillian N. Carrick (ORCID: https://orcid.org/0009-0006-0190-9699)
- Shridar Ganesan (ORCID: https://orcid.org/0000-0002-5404-3044)
- Manisha Bandari (ORCID: https://orcid.org/0009-0008-0329-6050)
- Nahed Jalloul (ORCID: https://orcid.org/0000-0002-8726-7060)
- Srilatha Simhadri
- Janice M. Mehnert (ORCID: https://orcid.org/0000-0001-9492-9264)
- Ming Yao (ORCID: https://orcid.org/0000-0002-9293-987X)
- Stephanie L. Murphy (ORCID: https://orcid.org/0000-0002-1052-9835)
- Katarina Stefanik (ORCID: https://orcid.org/0000-0002-4683-7266)
- Kavya Chettur
- Husam Al-Hraishami
Institutions
- Rutgers, The State University of New Jersey (US)
- Childrens Cardiomyopathy Foundation (US)
- Hackensack Meridian Health (US)
- Center for Discovery (US)
- The College of New Jersey (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1200/po.23.00260
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- U.S. Department of Defense
- Breast Cancer Research Foundation
- Rutgers Cancer Institute of New Jersey
- James N. Kirby Foundation
- National Institutes of Health
- National Cancer Institute
- Fogarty International Center