Cortical Tau Aggregation Patterns Associated With Apraxia in Patients With Alzheimer Disease
These results suggest that tau deposition in specific cortical praxis-related brain regions may induce local neuronal dysfunction leading to a dose-dependent functional decline in praxis performance in AD. The awareness of this relationship could further refine a differentiated individual diagnostic characterization and classification of patients with AD.
Authors
- Peter H. Weiss (ORCID: https://orcid.org/0000-0002-5230-9080)
- Gérard N. Bischof (ORCID: https://orcid.org/0000-0002-4366-5171)
- Sid E. O’Bryant (ORCID: https://orcid.org/0000-0003-0582-5266)
- Frank Jessen (ORCID: https://orcid.org/0000-0003-1067-2102)
- Elena Jaeger (ORCID: https://orcid.org/0009-0007-9387-3175)
- Kathrin Giehl (ORCID: https://orcid.org/0000-0002-0092-5164)
- Oezguer A. Onur (ORCID: https://orcid.org/0000-0001-8336-7075)
- Alexander Drzezga (ORCID: https://orcid.org/0000-0001-6018-716X)
- Esra Kara (ORCID: https://orcid.org/0000-0002-1090-6979)
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- German Center for Neurodegenerative Diseases (DE)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1212/wnl.0000000000210062
- Citations
- 4
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.37