Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs
Our dynamic 3D + 2D protocols produced an exceptionally high yield of hiPSC-SMCs. Transplantation of these hiPSC-SMCs results in significantly improved recovery of ischemic limb after ischemic injury in mice.
Authors
- Yuhua Wei (ORCID: https://orcid.org/0000-0003-0140-873X)
- Jianyi Zhang (ORCID: https://orcid.org/0000-0002-3955-6554)
- Yolanda E. Hartman (ORCID: https://orcid.org/0009-0005-0948-6101)
- Jason M. Warram (ORCID: https://orcid.org/0000-0001-5230-0011)
- Thanh Nguyen (ORCID: https://orcid.org/0000-0002-8440-1594)
- Lei Ye (ORCID: https://orcid.org/0000-0002-6529-6178)
- Akazha Green
- Xiaoxiao Geng
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s13287-024-04053-z
- Citations
- 1
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.18
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Biomedical Imaging and Bioengineering