TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate
Our data indicate that mucosal release of ATP and glutamate is responsible for the stimulation of colonic afferents following TRPV4 activation. These findings highlight an opportunity to target the gut mucosa for the development of new visceral analgesics.
Authors
- Sophie Oldroyd (ORCID: https://orcid.org/0009-0007-6954-6414)
- Michelle Meng (ORCID: https://orcid.org/0009-0001-2703-6957)
- Fraser Welsh
- Nathalie Vergnolle (ORCID: https://orcid.org/0000-0003-1825-6015)
- Ewan St. John Smith (ORCID: https://orcid.org/0000-0002-2699-1979)
- James R.F. Hockley (ORCID: https://orcid.org/0000-0002-9578-6071)
- Farideh Javid (ORCID: https://orcid.org/0000-0002-2775-6276)
- Matthew Thomas Harper (ORCID: https://orcid.org/0000-0002-4740-637X)
- Laurent Alric (ORCID: https://orcid.org/0000-0003-0676-7539)
- Étienne Buscail (ORCID: https://orcid.org/0000-0003-2040-3045)
- Róisı́n M. Owens (ORCID: https://orcid.org/0000-0001-7856-2108)
- David C. Bulmer (ORCID: https://orcid.org/0000-0002-4703-7877)
- Ivana Bello (ORCID: https://orcid.org/0000-0001-6103-8748)
- David Sagnat
- Luke W Paine (ORCID: https://orcid.org/0009-0009-4099-4648)
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Huddersfield (GB)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- University of Calgary (CA)
- École Nationale Vétérinaire de Toulouse (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- University of Cambridge (GB)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Recherche en Santé Digestive (FR)
- University of Naples Federico II (IT)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1111/bph.17408
- Citations
- 5
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- AstraZeneca
- Engineering and Physical Sciences Research Council