Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study
A flat dose is recommended over weight-based dosing. However, selecting a 1500-mg or 3500-mg dose may compromise either efficacy (MIC 2 mg/L) or safety (clinical breakpoint 8 mg/L), posing a dilemma. Clinical validation is warranted.
Authors
- Stefanie Desmet (ORCID: https://orcid.org/0000-0002-4338-1929)
- Matthias Gijsen (ORCID: https://orcid.org/0000-0003-1378-3772)
- Nada Dia (ORCID: https://orcid.org/0000-0003-1818-1949)
- Erwin Dreesen (ORCID: https://orcid.org/0000-0002-0785-2930)
- Willy Peetermans (ORCID: https://orcid.org/0000-0002-6974-8493)
- Peter Vanbrabant (ORCID: https://orcid.org/0000-0003-0217-3303)
- Isabel Spriet (ORCID: https://orcid.org/0000-0001-6342-0676)
- Sabrina De Winter (ORCID: https://orcid.org/0000-0002-5253-2960)
Institutions
- Pharmac (NZ)
- KU Leuven (BE)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1097/ftd.0000000000001279
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Onderzoeksraad, KU Leuven
- Universitaire Ziekenhuizen Leuven, KU Leuven