Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency
Our study demonstrates that ZnD leads to significant proteomic changes in the PFC and HP of rats. Specifically, ZnD alters the expression of zinc transporter proteins and proteins critical for mitochondrial function. The significant decrease in complex I activity in the PFC further underscores the impact of ZnD on mitochondrial function. These results highlight the molecular mechanisms by which ZnD can influence brain function and contribute to symptoms similar to those observed in depression.
Authors
- Monika Zaręba-Kozioł (ORCID: https://orcid.org/0000-0003-3544-6259)
- Bartłomiej Pochwat (ORCID: https://orcid.org/0000-0002-3785-6721)
- Łukasz Gąsior (ORCID: https://orcid.org/0000-0001-6417-9861)
- Bernadeta Szewczyk (ORCID: https://orcid.org/0000-0002-6863-7951)
- Andreas Martin Grabrucker (ORCID: https://orcid.org/0000-0003-0005-4810)
- Jakub Włodarczyk (ORCID: https://orcid.org/0000-0001-8928-8300)
Institutions
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- University of Limerick (IE)
- Maj Institute of Pharmacology (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1007/s43440-024-00681-7
- Citations
- 4
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 1.24
Funders
- Narodowym Centrum Nauki