Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores
We established a PRS model to serves as a valuable instrument for EM risk prediction. The exploratory analysis revealed that women with high risk of EM exhibited a higher height, suggesting EM related genetic loci may also influence growth and development level. Several risk factors were found to be potentially associated with EM, such as excessive familial contentment, COVID-19 vaccination, staying up late, and the husband's engagement in smoking and alcohol abuse.
Authors
- Yuexiu Liang
- Ming Zhou (ORCID: https://orcid.org/0000-0002-7033-954X)
- Sishuo Wang (ORCID: https://orcid.org/0000-0002-7220-7305)
- Yangyun Zou (ORCID: https://orcid.org/0000-0001-5034-9938)
- Yingying Xia (ORCID: https://orcid.org/0009-0007-4461-0969)
- Sijia Lü (ORCID: https://orcid.org/0000-0003-2469-1996)
- Qihang Wang
- Wenpei Bai (ORCID: https://orcid.org/0000-0002-1050-8460)
- Xiaomeng Bu
- Chunlan Song (ORCID: https://orcid.org/0000-0002-3750-7687)
- Mingming Shu
- Yuantai Fu (ORCID: https://orcid.org/0000-0002-6815-1708)
- Lijuan Lv (ORCID: https://orcid.org/0009-0004-7940-0775)
- Dingchuan Peng (ORCID: https://orcid.org/0009-0000-9588-6809)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-5555-0825)
- Wei Zhong (ORCID: https://orcid.org/0000-0001-9823-9500)
- Yuzhen Chen (ORCID: https://orcid.org/0000-0002-1951-8470)
- Wanyu Zhang (ORCID: https://orcid.org/0000-0002-5173-4181)
- Yiran Wang (ORCID: https://orcid.org/0000-0003-3753-2206)
- Linyan Zhang (ORCID: https://orcid.org/0009-0009-6138-171X)
- Yanrong Chen (ORCID: https://orcid.org/0009-0002-9952-6522)
- Chengyan Deng (ORCID: https://orcid.org/0000-0001-6832-7307)
- Wei Shang (ORCID: https://orcid.org/0000-0002-2218-0810)
- Yanmin Ma (ORCID: https://orcid.org/0000-0002-9477-2890)
- Yulin Chen (ORCID: https://orcid.org/0009-0009-5703-7991)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Maternal and Child Health Hospital of Sichuan Province (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Boai Hospital of Zhongshan (CN)
- Beijing Shijitan Hospital (CN)
- Chinese People's Liberation Army (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.3389/fendo.2024.1518288
- Citations
- 2
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.10