Influence of CReatine Supplementation on mUScle Mass and Strength After Stroke (ICaRUS Stroke Trial): A Randomized Controlled Trial
Creatine supplementation did not influence functional capacity, strength, or muscle mass during the first 7 days or outcomes 90 days after stroke. There were no serious adverse events associated with creatine supplementation. However, it decreased progranulin levels, raising a new possibility of creatine action. This finding needs further exploration to understand the biological significance of creatine-progranulin interaction.
Authors
- Sérgio Alberto Rupp de Paiva (ORCID: https://orcid.org/0000-0003-4412-1990)
- Suzana Érico Tanni (ORCID: https://orcid.org/0000-0002-2587-2759)
- Gabriel Pinheiro Módolo (ORCID: https://orcid.org/0000-0003-1057-5089)
- Bethan E. Phillips (ORCID: https://orcid.org/0000-0002-1430-1870)
- Philip J. Atherton (ORCID: https://orcid.org/0000-0002-7286-046X)
- Silméia Garcia Zanati Bazan (ORCID: https://orcid.org/0000-0002-0607-8189)
- Vladimir Eliodoro Costa (ORCID: https://orcid.org/0000-0003-3889-7514)
- Daniel J. Wilkinson (ORCID: https://orcid.org/0000-0001-8808-8243)
- Adam Gordon (ORCID: https://orcid.org/0000-0003-1676-9853)
- Paula S. Azevedo (ORCID: https://orcid.org/0000-0002-5843-6232)
- Marcos Ferreira Minicucci (ORCID: https://orcid.org/0000-0002-5980-4367)
- Leonardo Antônio Mamede Zornoff (ORCID: https://orcid.org/0000-0002-9831-8820)
- Maria F. Fernandes (ORCID: https://orcid.org/0000-0001-5649-3068)
- Marina Politi Okoshi (ORCID: https://orcid.org/0000-0001-7728-4505)
- Bertha Furlan Polegato (ORCID: https://orcid.org/0000-0002-2875-9532)
- Juli Thomaz de Souza (ORCID: https://orcid.org/0000-0003-2227-7505)
- Rodrigo Bazán (ORCID: https://orcid.org/0000-0003-3872-308X)
- Natália Cristina Ferreira (ORCID: https://orcid.org/0000-0002-2323-6310)
- Kenneth Smith (ORCID: https://orcid.org/0000-0001-8971-6635)
- Filipe W. Leal-Pereira
Institutions
- University of Nottingham (GB)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Arthritis UK (GB)
- Nottingham Biomedical Research Centre (GB)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Nutrients
- Published
- 2024-11-29
- DOI
- https://doi.org/10.3390/nu16234148
- Citations
- 4
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Institute for Health and Care Research
- NIHR Nottingham Biomedical Research Centre