Identification of ZNF652 as a Diagnostic and Therapeutic Target in Osteoarthritis Using Machine Learning
ZNF652 was found to be related to OA pathogenesis and can potentially serve as a diagnostic and therapeutic target of OA. The underlying mechanism is that ZNF652 was related to nitric oxide anabolism, macrophage proliferation, various signaling pathways, and immune cells and their functions in OA. Nevertheless, the findings need to be confirmed in clinical trials and the molecular mechanism requires further study.
Authors
- William W. Lu (ORCID: https://orcid.org/0000-0002-5780-2886)
- Rongyuan Liang
- Xifan Zheng (ORCID: https://orcid.org/0000-0002-6185-8778)
- Yeping Chen (ORCID: https://orcid.org/0009-0002-8499-3734)
- Yan Chen
- D. Q. Fang (ORCID: https://orcid.org/0009-0000-8119-4246)
Institutions
- Guangxi Medical University (CN)
- Chinese University of Hong Kong (HK)
- Youjiang Medical College for Nationalities (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s488841
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangxi Medical University