Molecular Characterization and Clinical Relevance of <i>MGMT</i>‐Silenced Pancreatic Cancer
MGMT silencing occurs in a small subgroup of PACs and is enriched in KRAS wild type cases, with a favorable prognostic impact. Our findings provide the rationale to explore combinations of alkylating with DNA damaging agents in MGMT-silenced PAC.
Authors
- Daniel Hübschmann (ORCID: https://orcid.org/0000-0002-6041-7049)
- Simone Rota (ORCID: https://orcid.org/0009-0006-9172-7003)
- Stefan Fröhling (ORCID: https://orcid.org/0000-0001-7907-4595)
- Massimo Milione (ORCID: https://orcid.org/0000-0002-1202-139X)
- Filippo de Braud (ORCID: https://orcid.org/0000-0003-0103-730X)
- Luca Agnelli (ORCID: https://orcid.org/0000-0003-0582-6170)
- Federica Perrone (ORCID: https://orcid.org/0000-0003-4406-8245)
- Daniel B. Lipka (ORCID: https://orcid.org/0000-0001-5081-7869)
- Andrea Franza (ORCID: https://orcid.org/0000-0003-2452-8099)
- Sara Pusceddu (ORCID: https://orcid.org/0000-0002-5096-660X)
- Giuseppe Leoncini (ORCID: https://orcid.org/0000-0003-3965-7635)
- Michele Droz Dit Busset (ORCID: https://orcid.org/0000-0002-5967-6828)
- Bruno Köhler (ORCID: https://orcid.org/0000-0002-7308-0377)
- Monica Niger
- Jorgelina Coppa (ORCID: https://orcid.org/0000-0003-2466-0524)
- Vincenzo Mazzaferro (ORCID: https://orcid.org/0000-0002-4013-8085)
- Marco Silvestri (ORCID: https://orcid.org/0000-0001-8283-9130)
- Federica Morano (ORCID: https://orcid.org/0000-0002-5306-3596)
- Giovanni Randon (ORCID: https://orcid.org/0000-0003-0244-445X)
- Paolo Ambrosini
- Chiara Pircher (ORCID: https://orcid.org/0000-0001-8173-824X)
- Federico Nichetti (ORCID: https://orcid.org/0000-0001-8044-4207)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Elena Tamborini (ORCID: https://orcid.org/0000-0002-3819-8687)
- Giuseppe Fotia
- Jennifer Hüllein
- Panna Lajer
Institutions
- German Cancer Research Center (DE)
- University of Milan (IT)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- Heidelberg Institute for Stem Cell Technology and Experimental Medicine (DE)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Epigenomics (Germany) (DE)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/cam4.70393
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.57