Population Pharmacokinetics and Dosing Regimen Analysis of Nirmatrelvir in Chinese Patients with COVID-19 Infection
This study showed that dosing regimen optimization of nirmatrelvir should be based on CrCl and body weight. Moreover, a web-based dashboard has been developed to facilitate individualized pharmacotherapy.
Authors
- Juehui Mao (ORCID: https://orcid.org/0000-0002-4338-7984)
- Yuetian Yu (ORCID: https://orcid.org/0000-0002-0193-4046)
- Nengming Lin (ORCID: https://orcid.org/0000-0001-5202-802X)
- Runcong Zhang
- Jiao Xie (ORCID: https://orcid.org/0000-0002-7115-829X)
- Weibin Fan (ORCID: https://orcid.org/0000-0001-7362-0348)
- Jing Fan (ORCID: https://orcid.org/0000-0003-2576-9302)
- Liang Sun (ORCID: https://orcid.org/0000-0003-1634-4716)
- Lu Han (ORCID: https://orcid.org/0000-0003-4808-5018)
- Bin Lin (ORCID: https://orcid.org/0000-0003-2222-8228)
Institutions
- Ministry of Education (NZ)
- China Pharmaceutical University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Chest Hospital (CN)
- Taixing People's Hospital (CN)
- Changzhou Academy of Intelli-Ag Equipment (China) (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s479561
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.90
Funders
- Zhejiang Medical Association
- Zhejiang Pharmaceutical Association
- Natural Science Foundation of Zhejiang Province