Designing and implementing the IDEAL Study: A randomized clinical trial of <i>APOE</i> genotype disclosure for late‐onset Alzheimer's disease in an urban Latino population
The <i>Información de la Enfermedad de Alzheimer para Latinos</i> (IDEAL) Study investigates apolipoprotein E (<i>APOE</i>) genotype disclosure among Latinos using mixed methods.We recruited adults 40-64 years of age without Alzheimer's disease (AD) for a community-based survey and randomized trial.Trial participants receives AD risk estimates with or without <i>APOE</i> genotypes.Psychosocial, behavioral, and cognitive impacts are assessed over 15 months.Findings may inform AD educational materials and genetic counseling protocols.
Authors
- Sophia Rodriguez (ORCID: https://orcid.org/0000-0002-3261-1944)
- J. Scott Roberts
- Ruth Ottman (ORCID: https://orcid.org/0000-0001-7074-242X)
- Jonathan D Godinez
- María Cabán
- Daniela Diaz
- Rebecca Ferber
- Cheng‐Shiun Leu (ORCID: https://orcid.org/0000-0002-0301-8316)
- Wendy R. Uhlmann (ORCID: https://orcid.org/0000-0002-4243-438X)
- Itzel A. Camarillo
- Jill Goldman (ORCID: https://orcid.org/0000-0002-4429-0279)
- Drew Blasco (ORCID: https://orcid.org/0000-0003-2524-5066)
- Karolynn Siegel (ORCID: https://orcid.org/0000-0001-8208-5949)
- Ana F Abraido‐Lanza
- John B. Wetmore (ORCID: https://orcid.org/0000-0002-5523-1004)
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Wendy K. Chung
Institutions
- Boston Children's Hospital (US)
- Michigan Department of Health and Human Services (US)
- University of Nevada, Las Vegas (US)
- Harvard University (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- New York State Office of Mental Health (US)
- New York State Psychiatric Institute
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/trc2.70016
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- National Institute on Aging
- National Human Genome Research Institute
- National Center for Advancing Translational Sciences