Esophageal Cancer-Related Gene-4 Contributes to Lipopolysaccharide-Induced Ion Channel Dysfunction in hiPSC-Derived Cardiomyocytes
This study demonstrated that LPS effects on cardiac ion channel function were mediated by the upregulation of ECRG4, which affects NFκB signaling. Our findings support the roles of ECRG4 in inflammatory responses and the ion channel dysfunctions induced by LPS challenge.
Authors
- Xitong Dang (ORCID: https://orcid.org/0000-0003-3076-6237)
- İbrahim Akın (ORCID: https://orcid.org/0000-0003-1974-6147)
- Huan Lan (ORCID: https://orcid.org/0000-0001-8027-448X)
- Lukas Cyganek (ORCID: https://orcid.org/0000-0001-9120-1382)
- Qiong-Fang XU
- Maolin Hao
- Bin Liao (ORCID: https://orcid.org/0000-0001-8317-031X)
- Xiaobo Zhou (ORCID: https://orcid.org/0000-0002-5895-0127)
- Xiangjie Zhang (ORCID: https://orcid.org/0009-0003-2810-4573)
- Qiang Xu (ORCID: https://orcid.org/0000-0003-4865-177X)
- Dan Tang (ORCID: https://orcid.org/0000-0002-0581-4017)
Institutions
- Heidelberg University (DE)
- Sichuan University (CN)
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Universitätsmedizin Göttingen (DE)
- German Centre for Cardiovascular Research (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s470828
- Citations
- 2
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Universitätsmedizin Göttingen
- Universität Heidelberg
- Bundesministerium für Bildung und Forschung