Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea

This study compared glycosylated hemoglobin (HbA1c) levels in the first and second trimesters of pregnancy and assessed maternal and neonatal outcomes according to HbA1c variations among women with pregestational diabetes. This retrospective, multicenter Korean study involved mothers with diabetes who had given birth in 17 hospitals. A total of 292 women were divided into three groups based on HbA1c levels during the first and second trimesters: women with HbA1c levels maintained at <6.5% (well-controlled [WC] group); women with HbA1c ≥ 6.5% (poorly-controlled [PC] group); and women with HbA1c ≥ 6.5% in the first trimester but <6.5% in the second trimester (improved-control [IC] group). The PC group had the highest pregnancy-associated hypertension (PAH) incidence, while the incidence did not significantly differ between the WC and IC groups. The receiver operating characteristic (ROC) curve indicated that HbA1c in the second trimester could predict PAH with a cut-off value of 5.7%. The PC versus WC versus IC group showed statistically significantly higher neonatal birthweight and significantly higher rates of large for gestational age (LGA); however, those were not significantly different between the WC and IC groups. HbA1c levels in the second trimester could predict LGA, with a cut-off value of 5.4%. Therefore, the second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes.

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Journal
Life
Published
2024-12-01
DOI
https://doi.org/10.3390/life14121575
Citations
3
Primary Topic
Gestational Diabetes Research and Management
Type
article
Field-Weighted Citation Impact
1.75

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article

Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea

Se Jin Lee, Hyun Sun Ko, Jin Gon Bae, Hyun Soo Park et al.
3 citations
Life
Gestational Diabetes Research and Management
1.75
article

Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea

Se Jin Lee, Hyun Sun Ko, Jin Gon Bae, Hyun Soo Park, Won Joon Seong, Seung Mi Lee, Ji Young Kwon, Mi Ju Kim, Geum Joon Cho, Sae-Kyoung Choi, Subeen Hong, Hyun‐Joo Seol, Ji‐Hee Sung, Han Sung Hwang, Gi Su Lee, Suyeon Park, Joon Ho Lee, Seung Chul Kim, Soo-Jeong Lee, Sooran Choi
article en
3 citations

Abstract

This study compared glycosylated hemoglobin (HbA1c) levels in the first and second trimesters of pregnancy and assessed maternal and neonatal outcomes according to HbA1c variations among women with pregestational diabetes. This retrospective, multicenter Korean study involved mothers with diabetes who had given birth in 17 hospitals. A total of 292 women were divided into three groups based on HbA1c levels during the first and second trimesters: women with HbA1c levels maintained at <6.5% (well-controlled [WC] group); women with HbA1c ≥ 6.5% (poorly-controlled [PC] group); and women with HbA1c ≥ 6.5% in the first trimester but <6.5% in the second trimester (improved-control [IC] group). The PC group had the highest pregnancy-associated hypertension (PAH) incidence, while the incidence did not significantly differ between the WC and IC groups. The receiver operating characteristic (ROC) curve indicated that HbA1c in the second trimester could predict PAH with a cut-off value of 5.7%. The PC versus WC versus IC group showed statistically significantly higher neonatal birthweight and significantly higher rates of large for gestational age (LGA); however, those were not significantly different between the WC and IC groups. HbA1c levels in the second trimester could predict LGA, with a cut-off value of 5.4%. Therefore, the second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes.

LifeVol. 14(12)
Seoul National University (KR), Kangwon National University (KR), Inha University (KR), Korea University (KR), Konkuk University (KR), Kyungpook National University (KR), Kyung Hee University (KR), University of Ulsan (KR), St. Joseph Hospital (US), The Catholic University of Korea Incheon St. Mary's Hospital (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Yonsei University Health System (KR), Pusan National University (KR), Keimyung University (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR)
Dongguk University, Kangwon National University, Kyungpook National University, Pusan National University, University of Ulsan, Yonsei University, Kyung Hee University, Inha University, Konkuk University, Kyungpook National University Hospital, Pusan National University Hospital, Inha University Hospital, Samsung, Seoul St. Mary's Hospital, Catholic University of Korea
Good health and well-being
Openalex Percentile: Top 14%
Gestational Diabetes Research and Management
1.75
DOIOpen Access PDFOpenAlex
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