Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study
While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.
Authors
- Don Smith (ORCID: https://orcid.org/0000-0002-1308-4595)
- Kathy Petoumenos (ORCID: https://orcid.org/0000-0001-7534-7154)
- Paul Yeh (ORCID: https://orcid.org/0000-0002-4172-3614)
- Nila J. Dharan (ORCID: https://orcid.org/0000-0003-1175-5962)
- Hossain M. S. Sazzad
- Robert Finlayson (ORCID: https://orcid.org/0000-0002-9981-632X)
- Gail Matthews (ORCID: https://orcid.org/0000-0002-1048-6396)
- Mark A. Dawson (ORCID: https://orcid.org/0000-0002-5464-5029)
- Mark N. Polizzotto (ORCID: https://orcid.org/0000-0002-6446-183X)
- David James Templeton (ORCID: https://orcid.org/0000-0003-2157-9587)
- Ian Woolley (ORCID: https://orcid.org/0000-0003-2928-1291)
- Jennifer Hoy (ORCID: https://orcid.org/0000-0002-6948-7086)
- Win Min Han (ORCID: https://orcid.org/0000-0003-3731-7960)
- Jane E. Costello
- Sarah‐Jane Dawson (ORCID: https://orcid.org/0000-0002-8276-0374)
- Ellen Bowden-Reid (ORCID: https://orcid.org/0009-0003-1597-7172)
- David Baker (ORCID: https://orcid.org/0000-0002-6811-8238)
- Mark Bloch
- Norman Roth
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- Peter MacCallum Cancer Centre (AU)
- Monash Medical Centre (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- Sydney Sexual Health Centre (AU)
- Monash Health (AU)
- Sydney Local Health District (AU)
- South Eastern Sydney Local Health District (AU)
- Melbourne Clinic (AU)
- Monash University (AU)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.xcrm.2024.101835
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- Gilead Sciences
- University of New South Wales
- Medical Research Council
- National Health and Medical Research Council