Analysis of the Dissolution Measurement Data Based on the Optical Spectral Detection

Using spectral detection to determine the drug dissolution is the main method of dissolution detection, in recent years, based on spectral detection circulation pool method has become some new dosage form of drug dissolution method, many studies at home and abroad have reported this kind of test, this for the investigation of drug in vitro release characteristics, predict its role in the body, so as to guide the clinical application has an important role. This paper first analyzes the commonly used drug dissolution method at home and abroad, using the traditional measurement method and circulation pool method for the dissolution of cinacalcet hydrochloride, and using the domestic commonly used measurement data analysis method to analyze the test results, to summarize the differences in the dissolution measurement. By screening the dissolution conditions, the dissolution test method of cinacalcet hydrochloride tablets in different media was established, and tested and verified. After determining the dissolution of drugs and reference preparations in different media, the similarity of the dissolution curves of the measured test samples was evaluated by the similar factor f2 method.