Activity and resistance mechanisms of the third generation tetracyclines tigecycline, eravacycline and omadacycline against nationwide Spanish collections of carbapenemase-producing Enterobacterales and Acinetobacter baumannii
Eravacycline remains a key agent for the treatment of bacterial infections exhibiting promising efficacy against multidrug-resistant pathogens. As an empirical antibiotic it could be a good alternative for severe infections caused by CPE or CRAB, however, its clinical use is limited by the absence of standardized breakpoints. Resistance mechanisms, including efflux pumps and gene mutations, vary among isolates. High-risk clones like K. pneumoniae ST307 and A. baumannii ST2 underscore the necessity of prudent antibiotic use.
Authors
- Cristina Lasarte-Monterrubio (ORCID: https://orcid.org/0000-0003-3351-2064)
- Michelle Outeda-García (ORCID: https://orcid.org/0000-0002-6737-0239)
- Juan Carlos Vázquez-Ucha (ORCID: https://orcid.org/0000-0003-4949-0779)
- Patricia García (ORCID: https://orcid.org/0000-0002-3817-4896)
- Alejandro Beceiro (ORCID: https://orcid.org/0000-0002-6340-7815)
- Andrea Muras (ORCID: https://orcid.org/0000-0003-1603-9762)
- Tania Blanco-Martín (ORCID: https://orcid.org/0009-0003-1636-6429)
- Jorge Arca-Suárez (ORCID: https://orcid.org/0000-0002-4248-503X)
- Romina Maceiras
- Paula Guijarro-Sánchez (ORCID: https://orcid.org/0000-0002-8456-0085)
- Isaac Alonso-García (ORCID: https://orcid.org/0000-0002-1681-969X)
- Germán Bou (ORCID: https://orcid.org/0000-0001-8837-0062)
- Lucía González-Pinto (ORCID: https://orcid.org/0000-0002-8387-3784)
- Arianna Rodríguez-Coello (ORCID: https://orcid.org/0009-0007-5066-3020)
- María del Carmen Fernández-López
- Andrea García-Pose
Institutions
- Instituto de Investigación Biomédica de A Coruña (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.biopha.2024.117666
- Citations
- 9
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.53