Molecular characterization of ST15 carbapenem-resistant Klebsiella pneumoniae isolated in a single patient
In this study, KP strains isolated from a single patient exhibited an alternating phenotype of resistant-sensitive-resistant-sensitive to carbapenems. The 9 KP isolates share a high degree of genetic similarity. The plasmid p2-KP3762-1, harbouring the carbapenem resistance gene bla<sub>KPC-2</sub>, may undergo inter-strain and inter-clone transfer via conjugation in the patient during treatment. Furthermore, our findings suggest that the pathogens in this patient are likely to have a common ancestral origin.
Authors
- Ruilan Wang (ORCID: https://orcid.org/0000-0001-9555-2649)
- Jian R. Lu (ORCID: https://orcid.org/0000-0001-5648-3564)
- Rong Tang
- Hong‐Yu Ou (ORCID: https://orcid.org/0000-0001-9439-1660)
- Yongjin Hu (ORCID: https://orcid.org/0000-0002-5882-9431)
- Shanshan Jin (ORCID: https://orcid.org/0000-0002-2047-8664)
- Jiahao Guan (ORCID: https://orcid.org/0000-0003-2909-7064)
- Xiaoxiao Meng
- Zengpeijie Dan
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1016/j.jgar.2024.11.003
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- National Natural Science Foundation of China
- National Key Clinical Specialty Discipline Construction Program of China