Epidermal Growth Factor Receptor (EGFR) and SMAD4 negatively correlated in the progression of gallbladder cancer in Eastern Indian patients
EGFR and SMAD4 expression were found to be negatively correlated in GBC tissue samples. ERBB2 overexpression/amplification was observed in 30% of the GBC samples. We also found a low percentage of GBC samples to show KRAS codon 12 mutation in Indian GBC patient population, as had been previously documented in pancreatic cancers.
Authors
- Shouvik Choudhury (ORCID: https://orcid.org/0000-0003-2913-1955)
- V.H. Sankar
- Sandip Ghosh (ORCID: https://orcid.org/0000-0003-0333-5992)
- Biswarup Basu (ORCID: https://orcid.org/0000-0002-5417-2735)
- Soumen Das (ORCID: https://orcid.org/0000-0003-0080-0860)
- Prosenjeet Chakraborty
- Kaushik Ghosh (ORCID: https://orcid.org/0000-0002-2972-6441)
- Nilabja Sikdar (ORCID: https://orcid.org/0000-0003-4465-472X)
- Sanjit Kumar Pal (ORCID: https://orcid.org/0000-0002-4720-2959)
- Shankar Prasad Saha (ORCID: https://orcid.org/0000-0001-5916-6046)
- Shibajyoti Ghosh
- Bitan Kumar Chattopadhyay
- Jitesh Midha
- Abhisek Mohata
Institutions
- Chittaranjan National Cancer Institute (IN)
- Institute of Post Graduate Medical Education and Research (IN)
- Indian Statistical Institute (IN)
- Medical College and Hospital, Kolkata (IN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1186/s12876-024-03485-4
- Citations
- 4
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Indian Statistical Institute