Lung contusion complicated by pneumonia worsens lung injury via the inflammatory effect of alveolar small extracellular vesicles on macrophages and epithelial cells
Lung contusion complicated by pneumonia increased the pro-inflammatory effect of alveolar sEVs on macrophages and the cytotoxicity of alveolar sEVs to pulmonary epithelial cells, worsening the severity of ALI. These results demonstrate the potential importance of alveolar sEVs in lung inflammation following a bacterial infection after trauma.
Authors
- William Johnston (ORCID: https://orcid.org/0000-0002-7082-7711)
- Katie Pool
- Wooil Choi (ORCID: https://orcid.org/0000-0001-7311-8171)
- Brian P. Eliceiri (ORCID: https://orcid.org/0000-0003-1811-1916)
- Jessica L. Weaver (ORCID: https://orcid.org/0000-0001-9194-8304)
- Todd W. Costantini (ORCID: https://orcid.org/0000-0002-0215-5327)
- Raul Sérgio Martins Coimbra (ORCID: https://orcid.org/0000-0002-3759-6851)
- Keita Nakatsutsumi (ORCID: https://orcid.org/0000-0001-6140-8761)
- Dong Jun Park (ORCID: https://orcid.org/0000-0002-4209-0302)
Institutions
- UC San Diego Health System (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1097/ta.0000000000004499
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Institutes of Health