In Silico analysis unveils rs2109069 of DPP9 as a potential catalyst for COVID-19 severity and risk of inflammatory symptoms
Our in silico findings reveal that severe COVID-19 inflammatory responses and inflammatory lung diseases share the same genetic risk loci, helping to elucidate the underlying physiological mechanisms of severe COVID-19 inflammation. Additionally, the individual differences in immune sensitivity may contribute to the varying multi-organ inflammatory effects among patients. The rs2109069 of DPP9 could be a genetic marker to predict the risk of specific COVID-19 symptoms and severity.
Authors
- Yung‐Jen Chuang (ORCID: https://orcid.org/0000-0002-6022-0107)
- Zih‐Yin Lai (ORCID: https://orcid.org/0000-0002-2694-9834)
- Chi‐Ying Lee (ORCID: https://orcid.org/0000-0002-9591-1370)
Institutions
- National Tsing Hua University (TW)
Publication Details
- Journal
- Experimental and Molecular Pathology
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1016/j.yexmp.2024.104946
- Citations
- 2
- Primary Topic
- Dermatological and COVID-19 studies
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Taiwan Semiconductor Manufacturing Company
- Ministry of Science and Technology, Taiwan