Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection
To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.
Authors
- Xiaoling Guo (ORCID: https://orcid.org/0000-0002-8547-4285)
- Qingdong Xie (ORCID: https://orcid.org/0000-0001-9320-7550)
- Xiaoyang Jiao (ORCID: https://orcid.org/0000-0002-7568-0595)
- Xin Li (ORCID: https://orcid.org/0000-0003-0469-5121)
- Meimei Wang (ORCID: https://orcid.org/0000-0003-3747-5432)
- Xiaomin Lin (ORCID: https://orcid.org/0000-0002-3480-0204)
- Yumeng Yuan (ORCID: https://orcid.org/0000-0001-8859-0698)
- Zeng Mi
- Fen Yao (ORCID: https://orcid.org/0000-0002-4959-0916)
- Xudong Huang (ORCID: https://orcid.org/0009-0008-8573-1596)
- Chun Lin
Institutions
- Shantou University (CN)
- People 's Hospital of Jilin Province (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
Publication Details
- Journal
- The Journal of Microbiology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1007/s12275-024-00190-5
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Shantou Science and Technology Project