Molecular profiling of head and neck squamous cell carcinomas in North-eastern Italy identifies possible tumour cell vulnerabilities
Our findings underlined novel differences in somatic gene mutations among the four anatomic sites. However, at present, the identified mutations cannot yet be considered predictive biomarkers either for the lack of supporting clinical findings or for the lack of approved targeted therapies in HNSCC. This underscores the imperative for continued investigation into the biology of HNSCC to unveil novel vulnerabilities that can be leveraged to enhance patient treatment strategies.
Authors
- Valentina Lupato (ORCID: https://orcid.org/0000-0002-9598-5951)
- Emanuela Vaccher (ORCID: https://orcid.org/0000-0003-3386-5142)
- Luca Pellizzari
- Giuseppe Fanetti (ORCID: https://orcid.org/0000-0002-9677-3176)
- Luigi Barzan
- Jerry Polesel
- Diego Serraino (ORCID: https://orcid.org/0000-0003-0565-8920)
- Roberto Doliana (ORCID: https://orcid.org/0000-0002-8324-7564)
- Vittorio Giacomarra
- Lorena Musco (ORCID: https://orcid.org/0000-0002-2726-7288)
- Gustavo Baldassarre (ORCID: https://orcid.org/0000-0002-9750-8825)
- Mónica Schiappacassi (ORCID: https://orcid.org/0000-0003-4804-4291)
- Riccardo Spizzo (ORCID: https://orcid.org/0000-0001-7772-0960)
- Giovanni Franchin (ORCID: https://orcid.org/0000-0003-2609-7974)
- Sandro Sulfaro
Institutions
- Azienda Ospedaliera Santa Maria Degli Angeli (IT)
- Centro di Riferimento Oncologico (IT)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.tranon.2024.102221
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- Ministero della Salute
- Regione Autonoma Friuli Venezia Giulia