Exploring the Impact of Dietary Factors on Intestinal Diverticular Disease: A Mendelian Randomization Approach

Dietary habits significantly influence the development of intestinal diverticular disease (IDD), a common gastrointestinal condition primarily affecting the colon. We performed a Mendelian randomization (MR) analysis on 20 diet-related factors using data from the UK Biobank. IDD cases (<i>n</i> = 33,618) and controls (<i>n</i> = 329,381) were obtained from the FinnGen Biobank. Three key MR methods were applied: the inverse-variance-weighted (IVW) method as the primary approach to estimate causal relationships, along with the weighted median (WM) and MR-Egger methods. Significant associations were found for pork intake (<i>β</i> = 1.06, <i>p</i> = 0.00244), nonoily fish intake (<i>β</i> = 0.709, <i>p</i> = 0.0449), oily fish intake (<i>β</i> = 0.246, <i>p</i> = 0.0222), and dried fruit intake (<i>β</i> = -0.953, <i>p</i> < 0.0001). After false discovery rate (FDR) adjustment, pork intake (<i>q</i> = 0.0244) and dried fruit intake (<i>q</i> < 0.0001) remained significant. Our results indicate that while pork and certain types of fish intake may elevate the risk of IDD, dried fruit intake may offer a protective effect. These findings highlight the potential of dietary changes in IDD prevention and management, though further research across diverse populations is needed.