Binding of Perfluoroalkyl Substances to Nanoplastic Protein Corona Is pH‐Dependent and Attenuates Their Bioavailability and Toxicity
Nanoplastics Nanoplastics serve as vectors for perfluoroalkyl pollutants in biological fluids, influencing protein binding behavior. Low pH weakens PFOS interactions while leaving PFOA unaffected, with PFOS still exhibiting greater serum persistence. Additionally, nanoplastics and serum albumin lower the cellular uptake and cytotoxicity of perfluoroalkyls by reducing their bioavailability. More in article number 2400255, Xingchen Zhao and co-workers.
Authors
- Yanmin Long
- Wansong Zong (ORCID: https://orcid.org/0000-0003-1027-1464)
- Jiaqiang Yao
- Xingchen Zhao (ORCID: https://orcid.org/0000-0001-6441-9394)
- Yan Bao (ORCID: https://orcid.org/0000-0002-9870-5943)
- Lining Zhao (ORCID: https://orcid.org/0000-0003-0311-7856)
- Henner Hollert (ORCID: https://orcid.org/0000-0001-5776-5619)
- Lei Feng (ORCID: https://orcid.org/0000-0002-6449-0307)
- Haimei Li (ORCID: https://orcid.org/0000-0001-7869-3407)
- Zongshan Zhao
- Jing Lan (ORCID: https://orcid.org/0009-0004-3595-7467)
Institutions
- Qingdao University (CN)
- Goethe University Frankfurt (DE)
- Shandong University (CN)
- Chinese Academy of Sciences (CN)
- Shandong Normal University (CN)
- Jianghan University (CN)
- Fraunhofer Institute for Molecular Biology and Applied Ecology (DE)
- Qingdao Institute of Bioenergy and Bioprocess Technology (CN)
- Hebei University (CN)
Publication Details
- Journal
- Small Science
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/smsc.202470055
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00