Identification of Key Post‐modification Enzymes Involved in the Biosynthesis of Lanostane‐type Triterpenoids in the Medicinal Mushroom <i>Antrodia camphorata</i>.
Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis. These post-modification enzymes could be used to synthesize at least 11 major Antrodia lanostanoids.
Authors
- Yang‐Oujie Bao (ORCID: https://orcid.org/0000-0001-5221-9360)
- Zilong Wang (ORCID: https://orcid.org/0000-0002-7875-0704)
- Yungang Tian (ORCID: https://orcid.org/0009-0004-2589-7210)
- Lei Ye
- Yuqi Wang (ORCID: https://orcid.org/0000-0003-0240-9048)
- Min Ye (ORCID: https://orcid.org/0000-0002-9952-2380)
- Yaqun Zhang
- Meng Zhang (ORCID: https://orcid.org/0000-0002-0540-5950)
Institutions
- Peking University (CN)
- State Key Laboratory of Natural and Biomimetic Drugs (CN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/anie.202420104
- Citations
- 3
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China