Brain changes following subchronic exposure to copper oxide nanoparticles: animal experimental data analysis
Abstract The goal of this study was to assess the health effects of (copper oxide nanparticles) CuO NPs on the brain structure and function in rats. Morphology results showed that the number of axons with the damaged myelin sheath in basal ganglia and the proportion of pathologically altered mitochondria in olfactory bulbs and basal ganglia had increased, while the concentration of myelin basic protein in blood serum remained unchanged. We also have observed the lower body weight gain, signs of hemolytic anemia, an increased platelet count, reduced locomotion and exploratory activity. We propose that the central nervous system and haematopoiesis are the targets for toxicity of CuO NPs administered intranasally during six weeks at the total dose of 0.45 mg/kg body weight.
Authors
- Liubov V. Toropova (ORCID: https://orcid.org/0000-0003-4587-2630)
- Ilzira A. Minigalieva (ORCID: https://orcid.org/0000-0002-0097-7845)
- Renata R. Sakhautdinova (ORCID: https://orcid.org/0000-0002-2726-9259)
- Marina P. Sutunkova (ORCID: https://orcid.org/0000-0002-1743-7642)
- Regina F. Minigalieva (ORCID: https://orcid.org/0000-0003-0013-6111)
- E. Yu. Petrov (ORCID: https://orcid.org/0000-0002-0945-8697)
- Ivan G. Shelomentsev (ORCID: https://orcid.org/0000-0002-8795-8777)
- Yuliya M. Sutunkova
- Karen M. Nikogoysan
Institutions
- Ural Federal University (RU)
- Ekaterinburg Research Institute of Viral Infections (RU)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- The European Physical Journal Special Topics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1140/epjs/s11734-024-01420-y
- Citations
- 3
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- Friedrich-Schiller-Universität Jena
- Ural Federal University
- Ministry of Science and Higher Education of the Russian Federation