SR3677 IS HEPATOPROTECTIVE IN MURINE LIVER ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BNIP3L/NIX (BCL2/ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 3-LIKE)
SR3677, a highly selective rho-associated protein kinase 2 inhibitor, administered prior to liver ischemia/reperfusion injury, induced hepatoprotection in both wild-type and Parkin2-/- mice. Experiments in hepatocytes identified BNIP3L/NIX, as a potential mediator of the hepatoprotective effects of SR3677.
Authors
- Ori D. Rotstein (ORCID: https://orcid.org/0009-0004-4388-5352)
- Earl G. Noble (ORCID: https://orcid.org/0000-0002-8182-4719)
- Menachem Ailenberg
- András Kapùs (ORCID: https://orcid.org/0000-0002-6610-9530)
- Raluca Petrut (ORCID: https://orcid.org/0000-0002-4353-6046)
- Avinash Naraiah Mukkala
- Rachel Goldfarb
- Katalin Szászi (ORCID: https://orcid.org/0000-0002-2490-8422)
- Vida Maksimoska
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- St Michael’s Hospital (IE)
- Unity Health Toronto
Publication Details
- Journal
- Shock
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1097/shk.0000000000002527
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00